I like this animation. It's pretty nostalgic, reminding me of Saturday morning cartoons I grew up with. Most notably, it has a spark of professionalism that most amateur works lack. I would not be totally surprised if some or all of the people who worked on this have professional or commission work experience.
The sound design is fantastic. It is even better than the visuals in my opinion. The voice actors are talented and passionate. The lead protagonist is especially convincing; it takes skill to use those cheesy one liners and not sound lame, let me tell you. I like her style in general. The musical cues are executed flawlessly, and the sound effects are satisfying. The music is cool as well, if maybe slightly generic. I'm getting faint Mass Effect vibes here.
World design, or what little I see of it so far, looks great. This opening episode does a pretty good job of grabbing my attention, introducing colorful characters in a self-aware fashion, and getting me interested in the world the Vampire Pixels live in, all in the span of around 2 minutes. It's just a shame there will probably be no further episodes.