I've seen this somewhere before
I found this mildly interesting, but only about as interesting as the original Super Mario; this isn't a parody, it's a re-skin. It needs *something* notable about its gameplay, because at the moment it has nothing that the gaming world hasn't gotten bored of about ten years ago. I think your audience at the moment will probably play the final game for about fifteen minutes, then go off and do something else.
The humour from the comic doesn't come across at all well: all you've got is imagery from the comic, overlaid on the game. There's no good reason for it being there, other than to say that this is an LICD Super Mario parody. I think there are other games that would make a better fit for LICD: the Sims springs to mind straight away. A little more work, granted, but then you'd actually be doing something with the LICD concept a little more; pimping up your lovenest and whatnot, occasional delusional fantasies into some form of more platform-based gameplay when Rayne goes off on one into Batman or LotR.
Actual programming and art wise, it's not a bad first foray into making a game. Obviously it's a little buggy right now (and for the smaller version of Rayne, that needs redrawing, not just being shrunk horizontally 50%), but it's reasonably solid. But with all these very positive reviews, that don't seem to mind that you've just made Mario again, I'd like to recommend that you don't stick your feet up. In terms of concept development and innovation, this is sorely lacking.