Missing something
While I love the strip, this game is lacking. As others have said, it's an okay Mario clone, but that's really it. You've replaced Mario with Rayne, koopas with those bible thumpers and goombas with those rednecks (or whatever the fuck they are). All I see here is just a conversion of Super Mario, with very little humor involved, besides the chuckles you get from knowing the source of a certain bad guy. Since the comic's main draw is the humor involved, this needs to be pumped up (in the storyline if there is one, if not through the gameplay itself).
The gameplay is kinda meh. Again, there's little there besides the visuals to differentiate it from Super Mario. Perhaps we're not far enough into the game to see some sort of Rayne-centric mechanic (like perhaps collecting enough tequila to turn him into bra-man), but something needs to be there. Let Mario be Mario, Rayne needs to be Rayne.