OH shit! Plot.
As the story unfolds, Frank and Brad have a series of violent encounters with Carlito, a mysterious Hispanic man, while Frank continues to come across a beautiful Hispanic woman named Isabela. Frank and Brad are eventually able to bring Dr. Barnaby and later, Isabela to the security room. Isabela reveals she is Carlito's sister and that Dr. Barnaby was the head of a research laboratory in the fictional Central American city of Santa Cabeza, the hometown of Carlito and Isabela. Dr. Barnaby, however, suddenly attacks Jessie and begins to show signs of zombification. When Frank questions him, he confesses that the research facility was attempting to find methods of mass-producing cattle, but instead, Barnaby and his team discovered an insect called a "queen" that would turn the cattle into zombies with a single sting. After one of the "queens" escaped and infected the town of Santa Cabeza, the US government sent a Special Forces team in to wipe out the entire city. The massacre was covered up under the pretenses that it was a raid on drug-trade operations. Outraged over the slaughter of his people and home, Carlito released "queens" in Willamette in revenge. After Dr. Barnaby reveals the true nature of the infection, he dies, and turns into a zombie, but is shot in the head by Brad before he can harm Frank.
The zombie outbreak in Willamette is only the tip of the iceberg, however, as Isabela later explains Carlito has much bigger plans. Hidden beneath the mall are five bombs that when detonated will release queen larva into the atmosphere, making a worldwide zombie pandemic a possibility. Frank is able to disarm the bombs in time to stop the explosion, but Brad is mortally wounded by zombies when pursuing Carlito. Frank and the remaining survivors turn their attention towards escaping to safety. Isabela reveals that Carlito has a hideout in the mall containing a laptop full of information, as well as a jamming device preventing Jessie from calling for outside help. Jessie tracks Carlito to an underground meat processing plant via the security cameras and Frank rescues him from an insane butcher, but is unable to acquire the laptop password from Carlito before he dies from his wounds. However, Carlito's dying request to give Isabela his locket helps her figure out the laptop password and deactivate the jamming device.
Jessie places a call for help, only to be told that another cleanup mission has been authorized instead; Special Forces soldiers arrive in the mall shortly thereafter, killing anything that moves. Frank makes his way back to the security room, only to find it empty save for two dead soldiers killed by Jessie, now zombified from Barnaby's earlier attack. A note reveals that Otis has commandeered a Special Forces helicopter and flown himself and the other survivors to safety. After avoiding capture by the Special Forces soldiers until they complete their cleanup mission, Frank makes his way back to Carlito's hideout and asks Isabela to come with him to the Helipad; she refuses. Frank makes his way back to the helipad to meet Ed. Unfortunately, a zombie finds its way onto the helicopter and attacks Ed, causing him to crash the helicopter into the middle of the mall's park. The game seemingly ends as Frank slumps to his knees in defeat, doing nothing to avoid the small group of zombies approaching him.
Still on the helipad, Frank is narrowly saved by Isabella, who shoots a zombie just as it is about to bite him. Frank passes out; he comes to in Carlito's hideout, where Isabella tells him that he has been infected, giving Frank just 24 hours before he becomes a zombie. However, Isabella believes she may be able to manufacture a cure from various items found in the mall, prompting Frank to scavenge for them. With the items Frank finds, Isabella is unable to manufacture a cure, but instead comes up with a symptomatic treatment which will temporarily prevent Frank from becoming a zombie. Accessing Carlito's laptop, they also discover the terrorist has placed 50 similarly treated children with foster parents across the country.
Turning towards efforts to escape, Frank discovers a tunnel underneath the park, uncovered by Ed's helicopter crash. The tunnel is packed with zombies, but with some more items gathered by Frank, Isabela is able to create a pheromone which repels them. Frank overpowers two Special Forces soldiers guarding the end of the tunnel and commandeers their vehicle to escape. They are intercepted by a tank, which overturns their vehicle. The special forces leader, Brock, emerges and reveals he was behind the original cleanup in Santa Cabeza. Frank jumps atop the tank, engages Brock in hand-to-hand combat and eventually knocks him into a mob of zombies surrounding the tank. Frank drops to his knees as he sees Isabella on the overturned vehicle struggling to remain out of reach of the zombies, but he is unable to assist her. Frank then screams into the sky as the game ends.
A text epilogue reveals that Frank was able to leave Willamette with credible information about the story, forcing the U.S. Government to accept at least partial responsibility for the Santa Cabeza incident, but denied connections to the Willamette outbreak. While the Willamette incident was widely reported, the American public eventually let it fade from their minds. No further information on Carlito's additional plan involving infected, symptom-suppressed orphans (mentioned in his laptop) was uncovered or verified, leaving its status uncertain.
The game ends with the text, "And yet he complained that his belly was not full."
Its only worth it if someone reads something they hadn't done yet.