Pass on your useless video game trivia here.
I'll start us off:
In Super Smash Bros. Brawl, Snake told Otacon that he just plum don't like Sonic. The joke for this is more apparent in Japan, where Snake is voiced by Akio Otsuka, the son of veteran VA Chikao Otsuka, who is the Japanese voice of Dr. Eggman and MGS4's Big Boss.
...which means Dr. Eggman is Big Boss! :O
When all else fails, blame the casuals!