Not bad
For an anime-ish animation, this wasn't all that bad. The graphics looked pretty good and the animation was pretty sharp as well.
Suggestions for Improvements:
The loop playing in the background when Spanio was playing RE4 paused for a second or so when it looped. Maybe you should try using a sound clip that lasts longer than the scene you need to use it for.
The voice acting seemed a little weak, especially that bit in the introduction. It just didn't seem to fit the mood all that well.
I noticed that some of the fbf was a little choppy. You should try put a few more inbetween frames for each movement.
Overall this was a decent movie with its ups and downs. I'm looking forward to your future movies.