Based on the popular comic strip, this live-action comedy follows the exploits of Garfield (Bill Murray), the large, lazy and wisecracking cat owned by hapless Jon Arbuckle (Breckin Meyer). Jon's other housemate, Odie, is a dim but sweet dog who frequently annoys Garfield. When the conniving orange feline gets fed up with Odie, he devises a way to get rid of the pooch. However, after Garfield has a change of heart about Odie, he must find a way to get his fellow pet back.