Keyboard controls would be nice. Moving your mouse around in four directions can get a bit tiring. Sliding would be better on a touchscreen device but if I had to choose between sliding the mouse in four directions and directional keys I'd choose the directional keys.
The colour coding is a bit difficult to decipher and some of the hominids look quite alike so it can get pretty confusing. If you don't want to add numbers to the squares than maybe you can colour code the whole background instead of just the outline. Some people haven't played this game before and may not know that the first square is numbered two so you might want to clarify that or just make the aim a certain picture or something but you can make squares higher than 2048 so I'm not entirely sure about this.
Sounds would improve the gameplay as well.
Then there's the issue of a whole lot of unused space. You can crop the stage or make the whole playing field bigger. I suggest using option two which allows you to make the pictures a bit clearer as well.
One last thing... You haven't utilized the description box to explain certain things about the game like how to play it, what your goal is, scoring, ect. I like 2048 so I hope you will improve on this in the future.