I got a chuckle out of this. I don't really know about the Isaac-ception thing or the end, but hey, what do I know??
Anyways, the animation wasn't bad, especially for a first time animation. I just think it could have been a bit cleaner. It felt a little jerky at times, like it could have used an extra in between frame to smooth it out. The lip sinking was a good start, that is always a pain in the ass to do!
Keep going! Get back to work! xD