You're on the right track!
Well, I really like it.
Yeah, it's basically Asteroids. But the little differences make for a great game! I enjoyed the Power Ups.. I had way too much fun blasting through the big germs in Invincible mode :)
The animation is killer, the controls are responsive, the gameplay provides an increasing challenge... what's not to like?
Of course there's always some way to improve. A couple details could use some attention (for example, "invincible" instead of "invisible" on the instruction screen). I did get a little bored with the background music; perhaps a longer loop would help here. Oh, and the shields always seemed to expire just as I was about to get hit. Maybe some visual indication that they're about to expire would help?
All in all, this is a great little game. And no, I haven't come close to your high score. But I'll keep trying.