First off, if it means anything to you, I have struggled with depression as well, but I managed to get better. I don't the specifics of your condition or your experiences, but let met wish you all the faith and strength you might need to find that authentic happiness once again, and not lose it.
Now for the actual review. This is a stunning piece, though I am slightly confused. To me, it initially seemed like a portrait of an abusive relationship: the woman is happy after presumably stabbing the mannequin in the face, which I thought might represent a man who lacks the necessary courage and love for the self to leave the woman. All he knows is her, and he doesn't want to know anything else.
Even if my interpretation is way off, I assure you that your skill is admirable and your approach quite powerful. Keep up the excellent work. :)