Wow, I wouldn't have the patience.
You have so many characters in here it's crazy. The only thing that you could do to take it a bit further is to put a little more detail into each character. When zoomed in the characters are well done, but very simple. So it looks like it would take a really long time, but a little bit of quality is lacking. Not much though.
It's so big that it doesn't look the best at full size. When it's small it's just a tad bit to small for you to really get to see all the characters. That kind of makes it fun though. It's like a trippy puzzle piece of art where your eyes just goes nuts with how much is going on.
This is a really cool piece all of around. I haven't seen anything quite like it yet on newgrounds.