I'm making a Simpsons cartoon and I'm trying to see if I can get it looking like one of the really old Klasky Csupo-era episodes. Don't think I'm quite there yet.
Here's how this went. I drew the rough keys and breakdowns in Flash, cleaned up and inbetweened it in Cacani, brought that BACK into Flash and colored and shaded it, drew the background in Flash with the brush tool (DON'T EVER DO THAT, IT SUCKS!!!!!), decided I didn't like the shading and deleted it (L O L), added drop shadows with the movie clip filters in Flash, then color corrected and added noise and other small effects in Adobe Premiere.
All of that for something that doesn't even look entirely like I wanted it to. D'oh.
(Also I'm still working on that silly Undertale thing.)