Other than simply finishing/completing it, have you ever just quit a game because of something that irked or frustrated you? I have two examples.
Cult of the Lamb
Although I did technically beat it, I did gave up on completing the DLC. One factor is I got real sick of taking care of my braindead followers! I gave them all the tools they need to have them clean after themselves but they refused to do it on the “special” poops. Why, if they’re so special, then why the hell do they taint the place like any other pile of crap. Then they get angry, and complain, some just turn on you: all because you were too busy to wipe their ass after they had an accident. But that wasn’t the final nail on the coffin. Before reaching the DLC, I swore to never sacrifice a single individual for any reason. It’s entirely possible to do it, but there isn’t much acknowledgment of it in-game. Probably because the DLC now forces you to sacrifice a follower to reopen the level doors. That got me dejected from the game altogether.
Voices of the Void
This game, I had one specific mission I decided to aim for, which later became two. Firstly, I wanted to have enough money to buy a tv so it will loop a playthrough of a specific game just to make the place feel more like home. Eventually, I had a secondary mission that immediately became top priority: buy the Sell Gun so I can make a lot of money cleaning up the whole base. It took three weeks and quite a bit of frustration, but I finally completed those two personal missions. I was real motivated to continue… until day 2 of my spring cleaning break. It was around that day where the aliens, that are basically the mascots of the game, decided to give me a gift: a full syringe and a note. The note claims “the medicine” can buff me up, so I took it. In hindsight, it was the stupidest decision I have ever made in a video game! I now loathe those aliens and I wasn’t giving them the satisfaction of continuing further after that stupid move. The time I play a future build of that game, I’m basically going to be an enemy to those freaks! Pro Tip: Do your research on strange syringe contents before taking them!