Sareena is a demon who made her first appearance in Mortal Kombat Mythologies: Sub-Zero as a non-playable boss character. She was first playable in Mortal Kombat: Tournament Edition for the Game Boy Advance and later in Mortal Kombat: Armageddon. She is from the Netherrealm and was an assassin for Quan Chi, but turned against him. Her young and beautiful appearance hides her true form of a hideous demon. In the past, she required Quan Chi's magic to sustain her human form, but since recently escaping the Netherrealm, she has managed to find a way to remain beautiful without him. She is now a force of good with an alliance to Sub-Zero and the new Lin Kuei, however, she remains wary of her natural demonic nature.

In Mythologies: Sub-Zero, Sareena, Kia and Jataaka wear clothes more revealing than any other female Mortal Kombat character had at that time, even Mileena. Their clothes were made with leather, making them even more provocative. They were designed this way probably to indicate that she was an assassin and a demon in a human appearance. In her Tournament Edition appearance, her outfit is similar to what she wears in Mythologies, the Tournament Edition outfit also appears as her alternate outfit in Armageddon.

In all her appearances, Sareena is shown to have a tattoo-like design over her face and white streak on her hair, just like all members of the Brotherhood of Shadow. The white streak may also indicate that she can only gain the appearance makeover.