When she was human, Mrs. Mayberry was blond and had green eyes. She is seen wearing glasses, a long sleeve shirt with cherry patterns, and a skirt that goes up to her stomach and down to her ankles. She appears to wear black leggings and black flat shoes.

In her demon form, Mrs. Mayberry retains her human self's body shape and outfit but with devilish features. She is roughly the size of Blitzo, with violet skin, pointed ears, red eyes with yellow pupils, and sharp yellow teeth. She has the same tail of an imp, but has noticeable goat-like traits like horns and dark purple hooves. She sports messy white hair, with a black, scrunchy scarf-like, headband. She has a dark pink shirt with noticeable stitches and an upside down red teardrop jewel on her chest with yellow on the tip. She also wears a black torn skirt, red earrings, and pink glasses.

Also, she is voiced by Mara Wilson; the older voice behind the brains of a child actor in Roald Dahl's Matilda.