Here we have a parody of the famous A Friend in Need painting, but with (some) famous flash characters instead. There's Fancy Pants Man from the Fancy Pants series, Robot from the Robot Wants series (With Puppy right next to him), The Parasite from Nitrome's Parasite, Simon from the Raft Wars series, Zakee from Geo Land: The Lost Time, Strongbad is in the background as a reference to his cameo in TF2 Poker Night. And if you look closely, you can spot Marsh from That Gravity Game on the game pieces, The Rider from Line Rider on the playing cards, and Snaily Snail from Snailiad in the painting. And if you look REEEEAAAALLLLY closely, you can spot jmtb02's Blue Elephant on the poker table.

There is also Rolling Rock. Aw yeah.

Video: https://youtu.be/fZjlHIkCjr8