Having played this for several years now I have to admit via Review that this game was worthy of a port to steam. I understand why many people still play this game.
Although having used an Auto Clicker (Via an old runescape clicker bot) for the first 10 asensions and having made new accounts via moving computers without transferring save files, I can say with little to no doubt that I've figured this out.
There are roughly 3 ancients that matter (THE MOST): Juggernaut; since the update where there are auto clickers for rubies ((I did grind to it so I could feel better about having used an auto clicker in the past)) Juggernaut has become a staple in every transcension, after leaving the game idle for several days I'd get roughly 500k x click combo and my DPS would be last to floor 400-500 ish.
I recently figured out that Combined with Solomon, a staple because of his AMAZING ability to add to your hero souls to insane levels, Morgulis is Important after you transcend a few times, reducing the cost of your ancients applies to his through the multi-buy, 1000 levels of Morgulis for 599 hero soul? YOU BETCHA!