Where to begin...
Well the title is misleading, as I see no sign of Deadpool anywhere, nor do I see any connection to the MVC3 video game that is so prominent on Newgrounds, and advertised in the description.
The animation itself is quite smooth, and the voice work doesn't have very much background interference, so that's a plus.
You were obviously going for this, but the buildings in the background look like the twin towers that were "taken down". I know several other Americans will notice this, and find it offensive.
If you put your mind to a serious effort at flash, I think you have some potential to really make front page.