OMG Last Boss.....
IS damn hard... I found his pattern but you have to be patient... Those freaking zombie alien things keep getting in my way when I'm looking to counter attack while he's doing the shoop.
Anyway though, I was mad at first due to the difficulty, but being the stubborn guy that I am I kept coming back to kick the last boss's ass. When you finally win, you really feel like you earned it. So far beat it with Tom, Dan, and Bob (Bob is a BEAST).
Also, a tip for guys having issues with the last boss:
When you start the game, save *ALL* of the guts/health that falls from the enemies. Heal yourself on the slots minigame after Mindchamber, and play defensively until you get to the last boss. If you get caught in the laser twice in a row, or if you're low on health you can heal yourself with the guts/health that you have stockpiled.