Do you know the Spider-man artist Paolo Rivera? This work reminded me of his. I find his work phenomenal. The first time I read a Spidey comic by him (drawn and painted by him, I believe) I was blown away by the realism and the strong clair-obscure contrast in the strokes. If you don't know him, you should really look him up :)
I love how you painted Spidey - great lighting shades, the muscles, movement, perspective and the paint strokes - and how you made the angle work in the composition. I have only two pointers - which are probably more taste-related -: Spidey's left foot's shape looks a little off, like the ankle is too thick or the sole on his heel is not high enough, and the shading of the building above Spidey's left shoulder and the roof behind him. I think the way they are painted a little flat in comparison to the rest of the picture. Perhaps this is because they are background forms and you want to take focus away from it. This is only my humble suggestion, but perhaps you could try rougher strokes on them to bring more depth in texture in them.
I think this image is great and my review became a lot longer than I intended! I hope my feedback could be of use to you.