Too slow, Joe...
The pacing is really slow... too much time in between each person talking, and each character takes about a year to say his line. You don't have to cut out MB's by not lip-synching, you can do it by laying the audio at a faster pace.
The slowness ruins the comedy. Comedy needs good timing and a fast pace to work... so speed it up.
The art was good, except the backgrounds. You should have hand-drawn those as well, it would have looked a lot better.
And as for your question about the lip-synch... I would rather have good lip synching and higher file size. It doesn't matter to me, I have cable so it's all fast. Screw the 56k crowd... they should step up into the '90's and get themselves DSL or something.