Super moody and cinematic.
The bass has a super slow release. I'm not sure if this is the synth/sample or if it's an effect, but it works in some places better than others. When the bass moves faster (such as the rising section in 2:22), the decay fights the onset of the new note and causes a moment of dissonance between the notes creating a bit of muddiness.
In general I could use some more layers of some upper percussive layers. You have good driving motifs in the lower and mid layers, but picking out a few places to bring in some textural layers of clacks, shakers, tiki tikis, could really help accentuate some of the sections and create more dramatic shifts when you pull them out. For example, if you added some subtle layers starting at 0:30 (and suddenly shift to a different layer at 0:47) it would make the muted synth/harp section at 1:02 REALLY stand out.
The same goes for 1:41. You could build layers of activity leading up to this, and then if they suddenly dropped out for those drones/flute to take over, it would feel gosh darn epic. it's a great way to subconsciously build tension.
2:57 - after the cymbal cresecendo, I'd consider adding a bass drone an octave below the current bass in a sine wave or something to really help that section pay off. Right now the crescendo leads into something, but the texture remains largely the same as it was leading up to that point. You could go all Disney Magical Moment with it too and layer in some super subtle tinkling of a mark tree, though it's up to you if you wanted to go that route or not.
All in all, it's really great. I think you accomplished what you set out to do. The midi instruments didn't stand out, and you did a good job of balancing it with live recordings. Well done!
FYI, I'd look into the possibility of using Vienna Ensemble Pro to help offload some of the duties of your workstation if you're having trouble keeping up with running all the virtual instruments. Not everyone loves the extra layer of tech it adds, but I've found it indispensable when it comes to large ensemble work.