Enjoyed the animation and I think its a pretty nice piece. Particularly found the color scheme a nice compliment to the retro vibe of the whole 90s video-game thing, But it has several flaws that are holding it back (IMO).
The tone and atmosphere of the whole thing is rather inconsistent. While you did say in a previous comment that the more comedic elements were intended to make the scare more hard-hitting or more of a shock, there just isn't enough time to get comfortable in the more relaxed atmosphere for the intended amplification of the horror to work. It's not your fault as you're restricted by it being a flash short, but I'd recommend sticking to either pure horror, or at least generating the dark tone (even if it's subtle) from the very outset.
Another issue (related to the one above) is how the comedy sort of bled into the horror part of it (if I may divide the film into two parts for simplicity's sake). Some rather comical/non-serious things happened (I assume they were intentional) occurred into the sinister part of the film. The humorous elements, such as how the demonic cartridge talked and Tiff's 'sass' served to ruin the atmosphere rather than improve it. It made it harder to take the villain and it's menace seriously.
Also at the end with he whole "So what have you and Vortex been up to?" line was rather unnecessary. I assume you were trying to create a sense of helplessness (like in Texas Chainsaw Massacre when Sally is stuck at the dinner table while the Sawyer family just argue among themselves), but the atmosphere isn't there and something about that line just doesn't fit. Also, it doesn't leave us with a sense of dread or impending doom, as Tiff's arms and a leg have already been ripped off. That visceral part was basically already the climax to the whole thing.
Anyway, I hope my feedback made sense, and I hope you keep making videos