Good game. Good UI, nice if limited mood music, solid systems but not much in the way of direction or real development of gameplay.
Thriller genre uses the most skill categories, giving you the highest quality work if your skill points are evenly spread. Thriller - unsurprisingly - works best with a Betrayal, Horror, or Mystery theme.
Going through a publisher is much more lucrative than self-publishing. Depending on the Quality and Combo of your work, different publishers will be interested. Best I've found is Wilkes with 50 quality and 18% royalties.
Buy the improvements you can afford, prioritizing Writing first, then Transportation, then Living; spend skill points evenly. You could try randomly determining which genres utilize which skills, and from there find the best bang-for-buck skill combination to invest in; but that's a lot of trial-and-error analysis and I'm already a millionaire author, so pass. Good game.