This is a really interesting game, and the depths of complexity it reaches are surprising, but I'm really frustrated by the interface. Buttons almost never work the first time I click them, and in the Knowledge and Exam menus the button to get back often doesn't work at all, forcing me to reload the game.
Additionally, the structure of the interface is also confusing, and there's no guide (or if there is, I can't find it). For instance, statistics are nested in the configuration panel, and the selling of atoms is split between three tabs, one of which sells them bundled as molecules. I've been playing this on and off for weeks now and I'm still getting confused.
The mission parameters are also often vague enough that I have a hard time telling what I'm supposed to do. Lastly, I can't get the medals to work, and clicking on the NG logo like the instructions said didn't do anything.