Hot Keys
Let me start by saying I really, really want to like this game. I like the whole "angels and demons" thing, and the battle system is really kinda fun.
But seriously... The exclusion of hotkeys doesn't just create a more unfairly difficult game, it actually almost breaks it. I've never created a game, so I don't know how difficult it is to do, but removing a feature like hotkeys because it would make the game more challenging is like removing graphics. Sure, it'll be challenging, but not the good way. Why not make the battles harder, instead of the control scheme?