A poor emulation of Okami
As far as the animation goes, while characters' movements look poorly done, the scenery and drawings themselves are marvelously done. I applaud you for that. This is, however, a game, and I'm grading you on more than just looks.
The gameplay was weak, as most of the game involved moving the character up and down the screen, trying to decipher background from enemy. Again, while everything looked beautiful, the depth made it difficult to tell what was good and what was bad. In addition, there was no real way of the player knowing what they were supposed to collect and avoid, as the "How to Play" section was basic and hardly informative.
As far as the sound goes, the music is repetitive and cliche. The sound effects are unoriginal, and I find it tremendously tacky to use sounds from other video games (Sonic the Hedgehog for example, like you used).
A user below, Spearclaw, mentioned this being similar to a PS2 game, I'm assuming Okami, in which a wolf brings color and nature back into a bleak world corrupted by evil beings, all with an underlying theme of paint brushes and art. This game would have passed off as a dedication or a work of inspiration had it been better gameplay wise, but it fell short and just looked like a weak emulation.
Your art is very strong however, and though your game creation is weak, I'm sure that you will excel if you focused more on producing artwork on Newgrounds. A valiant effort.