As usual. ^_^ I really love all the "Little" (Should be read TINY Writing) Things you add into your animation, I really liked the progress report you have behind the cheerleaders. ^_^
My stand on tRip is that the pill is there to suppress peoples emotions, the people inside the heads are all the range of emotion that everyone has, all the male emotions are basic and straightforward, like the flexing competition later in this film, and all the female roles are ones focused on learning and silly mischief. The special one fighting the pill is undoubtedly the rebellious nature in us all saying "I don't want to follow the rules and I want to be myself"
In that setting, the pill wants to destroy every emotion in the mind and leave nothing there but the drone left behind, a blank slate for the mad scientist to do what his evil mind wants. But the one thing in it's way is the rebel fighting to keep itself and all the other emotions safe.
That template also fits in with the first movie because of the change of scenery two different people have two different minds (How they grew up and the life experiences make them think differently) But the base emotions are the same so the rebel is still there along with all the other characters.
I really Love your work and I hope to see some more of your work soon. ^_^