Tough to review...
Barring the fact that I'm not a LOST fan (I think it's a cool concept, but too ridiculous and poorly written to justify the following), this game is just hard to get into.
To make it more appealing/welcoming to non-LOST fans, you could start with a brief introduction via voice-over or text. Just give us a little background, or, at the very least, help us identify with our character a little bit.
The Photoshopping is... Average. The seams need a little blur, which you could justify by having just been in a plane crash. Also, the composition is very much in the vein of 'WTF?' The sheep spraypainted with the number '23' were a little much, and everything not in the original shots sticks out like a sore thumb. But I can't click them!
Additionally, the navigation is confusing as hell - try to limit it to two, maybe three arrows, or give us clear paths. Otherwise we just click at random, without a clue as to where we should go.
A valiant first effort, Sir, but it's just too much of an homage to LOST for me to really judge fairly. Maybe if I were a fan of the show I'd have been a bit more familiar with what the hell was going on, but as it stands right now, I need more. More storytelling, more background, more introduction. Toss in an interface that... Well, doesn't exist, and I'm as lost as the protagonists of the show.