This was pretty fun, it's always great to see more indie cartoons by people who obviously care a lot about making cool stuff.
There's been a lot of feedback regarding the animation (all definitely worth listening to), so in the interest of not telling you what you've already heard, I do have some major feedback for the backgrounds.
I think the backgrounds are should be a major focus for improvement for the next episode. The first thing I noticed in the beginning when the pair were waking up was their rooms looked exactly the same - a bed, a lamp, and maybe a poster. That's it. The BGs in general suffered from a lack of detail, which made the world feel more sparse.
The best advice I can give for good backgrounds is to treat them like characters in them selves. An environment like a bedroom or a bar picks up the personalities of the people who inhabit it. Maybe we could see Elliot's charger next to his bed and medical books on his shelf, Trent's hamper overflowing with dirty laundry. What kind of computer would Elliot have, how many empty beer cans or food wrappers would Trent have on his floor? If the hospital is so bad, how about a hallway with a flickering light and suspicious stains on the floor? If the bar is serving bad booze, maybe instead of plain boxes there could be shelves covered in dust and cobwebs?
Obviously you don't wanna go too crazy detailed with the backgrounds, since you've got a simpler, cartoony style going. Nothing wrong with that. However, some more attention to detail, designing the environments with some personality to them to make them feel more lived-in, will make this project feel much livelier and more cohesive.
All in all this is a really strong start. By reading the comments I can see your team is being super receptive to feedback, which is a HUGELY good sign. With your kind of attitude I have no doubt that you'll continue to improve and make this show better and better.
I'm looking forward to the next episode!
Oh, one last thing - "Onion Skin Studios". From one animator to another, nice one ;)