I'm gonna be a bit tough on this one.
Starting off with the game design; overall it's unique, and I like the inclusion of a High Score system (Did you know Newgrounds API has a High Score system http://www.newgrounds.com/wiki/creator-resources/flash-api/reference/api#wiki_toc_21, If you know how to use the API I recommend it),
but I think score should be based off of how long the player is able to keep the civilians alive, rather than how many civilians are left at the end of the time (that's just personal opinion). Something that bothered me was that sometimes the civilians on fire can run faster than I can fly, there were multiple cases where I was trying to put one out, but it ran away and died. I think maybe making either the civilians slower or the protagonist faster could be a solution.
Next I found the constant screams of the civilians loud and annoying, and the music (while decent sounding) doesn't seem to match the game play. I personally would've chose something faster and more intense.
Furthermore, I found the graphics, not bad, but inconsistent. I personally dislike inconsistency a lot (an example would be the shading on the shirt/jacket. Some of the pixels are smaller than others.)
Lastly for a game that was made in 48 hours I would say it's pretty good (It's definitely better than some games I've seen before).
I give it 3.5 Stars.