The eldest brother of the family, Father Paul (Newman), and his nephew Rocco, team up together to stop Paul's mentaly insane brother Walken (Christopher), from killing the President of the United States, Bill Clinton. Walken has been in jail for 30 years and now free, is once again running the BRONXBROTHERS family business of crime in New York with his underboss Sharky(Sean Penn) and the corrupt Senator of New York, Mel (Gibson). Walken has a son named Junior, as his bodyguard, and a daughter named Angelina (Jolie), as his top assassin. Her soon ex-husband, Johnny (Depp), a gypsy heroin addict, has taken incriminating photo's of Walken's business partner Senator George Bush, in an attempt to blackmail him to get Angelina back.

This is the story of a criminal family empire lead by the BRONX BROTHERS. The youngest brother, Marlon, is the charming, goodlooking, boss of the family. While his elder brother, Walken is an evil tormented psycopath in and out of jail, who is secretly killing off the entire family out of jealousy and a desire to rule the underworld as the sole BRONX BROTHER. One brother out of the five BRONX BROTHERS, has taken the responsibilty of stopping two of his brothers that are pure evil, middle brother Tony and 3rd oldest brother Walken, his name is Paul, and he's a priest, and the eldest. When family members or Mary's family members are kidnapped and/or murdered by Tony or Walken, Paul asks his nephew Rocco to help rescue, as Rocco's father is the fifth BRONX BROTHER, his name is Jack, the second eldest brother, and also very charming and rambunctious. All his life Rocco avoided the family business, choosing to be a doctor instead. He has a beautiful love named Mary, and they have a wonderful life together...until Walken and Tony try to destroy it