This game is Awesome
I bought this game on steam last week and am loving the replay-ability of it. Each Level is randomly generated with randomly generated items. there are tons of powerups and weapons to use. The bosses are all very unique and interesting. and the ending is scary as hell. I personally still havent defeated mom.. her damn thieghs are just so .... fat... Anyone who's got 5 dollars to spare should definitely pick up this game. Its got hours and hours of replay-ability including previously mentioned random levels and items. Unlockables the further you progress that include new characters, new weapons, new utility items. Also you really start to feel for Isaac the more you play. It seems like the more you learn about his life the more you want him to succeed.
In short.. BUY THIS GAME!
~ThelukeSchnabel (view my letsplay on youtube under the same name)