The overall concept is good and the game is fun to play for a while, but the lack of realism in (even in realistic mode) can be frustrating.
Case in point: A completely harmless and asymptomatic disease causes widespread panic, closing of airports and shipyards, etc. after its infection rate increases. But how is it possible that people even knew they were infected in the first place?
The government and scientists truly seem to have psychic abilities. Within less than an in-game day of my virus gaining the ability to spread via insects, governments around the world were using pesticides to reduce insect populations in order to combat this.
There is also the fact that once a country closes itself off completely (I'm looking at you Madagascar, with your lone port of entry), then it becomes effectively impossible to infect that country (even if the virus is airborne and an adjacent nation has a 100% infection rate). At this point the game becomes unwinnable, and considering how jumpy some governments are, this can become a serious issue.
Despite these flaws, I can't help but like the game. The premise is pretty cool, and if you simply accept the fact that 10% of the world is almost impossible to reliably infect, then you can still have fun with this game. There is enough strategy involved to keep things interesting, even if your best laid plans are occasionally thwarted by governmental paranoia.