I'm sure all of this has been addressed before in this thread, but I just wanted to say how I feel about the whole thing.
I hate it. Granted, the old layout wasn't perfect, but this is just broken, and no amount of tweaking is gonna save it.
The autoplay lags everything, and it's a security threat (I know that submissions that are UJ don't play automatically, but people can always swap the files after the movie has passed). It's also kinda inconvenient, since a lot of people like to browse other pages while the movie loads in its own window, or want to close the movie but keep reading reviews or authors comments. I also want to have the ability to at least check the little icon (if I'm viewing from the portal page) or author (if I'm viewing from front page) of the movie before I let it start loading.
The whole fullscreen thing is also awful. Flashes are obviously going to look worse when viewed differently than they were intended to. There are lots of small mistakes that are unnoticeable at 550x400, but really stand out at fullscreen. The same applies to stuff that has raster graphics in it.
Authors and the authors comments will get ignored now, since they're completely pushed off screen by the flash. Stuff will get a lot less votes and reviews now too, for the same reasons (though maybe that isn't so bad, seeing as how the credibility of those systems has been completely ruined by the people who only vote 0/5 and 0/10). I don't see the logic in giving the artist less attention than 'stuff you may enjoy'.
The 'stuff you may enjoy' thing is also broken btw. I know Tom pointed out that the system will be worked on, but how is it that Oh Oh Sexy Vampire is a recommendation on, like, every page? The system didn't work before, but at least it was tucked away in a small corner of the page before.
Plus, I'm sure you'll change this soon, but the header looks ugly too atm.
But really, I shouldn't be surprised, since Newgrounds doesn't care about artists nearly as much as it used to. What matters now is that you have more space for ads and video game parodies.