aggravating but cool harmonies
and a kickass title...lead melodies could definetly drive me insane but I personally like it.
Interesting, queer opening melodies on that thin snyth....I especially like the backing organ melody...the thin melodies work really well too, too add more epicness I would include a bold saw in here with some intense drums (say right after the 2:00 part), I think that would help quite a bit...Another good melody around 1:20, and another nice harmonization riff...lots of variety in here, but you could try expanding on the melodies more. Glad you included bass in here, I think it could use a more bassy tone tho-sounds a bit boring when it plays by itself..
now there are countless ways of ending sounds by messing them up, but including sharp loud noise isnt one of them-thought that was quite unnecessary and you could have put more effort in wrapping up your track.
and replace those lame drum samples I wont be the only one to tell you :P try panning your hi-hat a little more to the left or right, and the snare sample could be raised a tad.
Aside for sounding a little too much presetish(which makes some sections cheesy) freaky mix, keep up the good work.