Dude, that looks exactly like Deadpool does in the comics! It seems just like what official artwork would churn out! Powdered Toast Man looks a little updated for a more modern comic book appearance, which is great. I guess he's not really a meta guy like Deadpool, but both are at least involved in wacky adventures. Of course, Deadpool would be one who would engage in activity with any crazy character. A bit nonsensical, but still great.
The background is also good, because it fits the stereotypical action comic book. I would love to see this developed into an actual comic book. I love how confused Deadpool looks. The lines and body movements are really well done and emphasize the parts well. I've been saying John K. is a big art influence to many people, but I think this is the first actual fanart featuring one of his characters.