Very Cool; the Background Just Seems "There"
The sneezer's expression and posture is golden, one of embarrassment and massive guilt. Her companion should be wincing or have narrower eyes than that, although she might be surprised. Far be it from me to nail someone for anything, but the background appears fully digital and, therefore, fully plain. T'would be far better to integrate images that were originally hand-drawn onto a background that started out hand-drawn to some degree.
Then again, this does look like the single frame of a well-polished television cartoon from the early '90s, or even the sort of Looney Tunes/Merrie Melodies fare before Chuck Jones' Spartan Abstract style debuted (particularly with Road Runner/Wile E. Coyote). In other words, the look and feel of the piece brought me back, and in a good way, as if it was "Rabbit Season" once again!
P.S. City of Villains sounds cool. My mother, it so happens, plays City of Heroes. One of her characters' names is Scarlet Knightingale (I think).