I love how you've subtly blended the looks of the cartoon Leela, with the real life Katey Sagal, particularly around the mouth - it looks very powerful and yes, of all of the aliens out there, I would love to get to know this particular specimen (okay, we all know she's really a mutant, but who cares) a lot better.
Perhaps you overdid the shading on the abdomen part of the top, since her breasts are not that massive to have their own gravitational pull, dragging light away from her stomach quite that much.
Other than that, the curves are great, her eye is fantastically detailed (I can see that an expression for the monobrow would have been difficult to conceive, with no real reference to draw upon, so I won't criticise. Her hair is another high detail area with what seems like each individual strand painted in, which must have taken hours.
Certainly one to come back to and admire again.