Oh man this was so bad i actually thought i was watching a LoL cartoon, congratulations man.

The animation could use some work but overall it was pretty good.

Feel like I have to be a hardcore Dota 2 Player to understand this animation. Did enjoy that voodoo witch voice acting though.

In an animation perspective, you seem to have potential judging by that rhino-centaur-man's run cycle, however this level of craft wasn't applied to the characters' talking and joking, it feels like as though you've pieced each appendage of the model together and turned their arms and heads around with the move tool or something. I think you'd do great with if you hone your animating skills to more than just this run cycle rather than to take the turn most computer-based 2D animation take today; look at Atomic Betty for example of what to avoid.