I think this series has some real potential, but the future games really, really need some way of seeing whether you are about to click on a blank area, pick up/use and item, or move to another screen. Nothing fancy is needed, just like an arrow showing up when you're hovering over a region that changes screens when you click on it.
The reason I think this is so important is that I spent the entire game fighting the controls, trying to click on things, only to have the character turn and face some other direction.