I play a Hamer Monaco Elite for my primary guitar - these things are handmade in Connecticut, cost as much as Gibsons, but blow them out of the fucking water.
My secondary (for songs in drop-C tuning) is an ESP EC-500, which is a really solid guitar for the price.
I play through a Marshall DFX-100, which is a really solid combo amp. 100 watts, 12 inch speaker, nice built in distortion and effects.
Of course this is gear I spent 4 years amassing and practicing my ass off with. If you're just starting, go for a Squier Strat-Pack, where you get everything you'll need for under 200 bucks. It's not mind blowing quality, but it's enough to get started. Alternatively, find a cheap amp for under 100 and grab a used guitar from a pawn shop. You can get great deals there.