After about 100,000 votes, the scores tend to even out.
My personal theory to keep a larger score is to do a littlefoot/Ultimateshowdown.
Submit the entry shortly after the weekly awrds are handed out. After you submissions gets a really high score, it'll get a Front Page. It'll spend say, one week one the front page with great, non-biased audience. Then After the week is done you'll have like 20k non-down voted votes. After the weekly's are given out and your submission gets on the Top50, then pray your Front Page stay lasts pretty long, so that the fair votes out weigh the Auto-0ers.
Then again, anybody who is good enough to make 4.2x flashes don't give a fuck about the Top50 in actuallity.