Whoops - I forgot to nominate my other fave (can we nominate more than one entry?)
"Ed and His Inner Demons" by Kevin Swearington. I had it on my favorites page since it came out, yet no one seems to have seen it. It's got evil comic demons who run amok in Ed's brain, and Smileymen whose heads blow up with "happiness" What's not to like?
http://www.newgrounds.com/portal/view/37 9556
"Proof" by mike mac - about a camera-ready scotsman and why you will never ever see pictures of the The Loch Ness Monster.
http://www.newgrounds.com/portal/view/38 0226