As a serious hard-head with hereditary sleep issues, let me explain the basic chart of how this goes:
day 1: Normal day. You had a good night's sleep the day before.
night 1: WOO HOO! Sleep deprivation adrenaline! Let's drink all the booze!
day 2: Sleep deprivation kicks in. Cranky and frazzled, getting by on nervous energy and coffee. Lots of coffee.
night 2: You are either on drugs or dealing with some serious bullshit. This is the point where even insomniacs toss back an ambien. Unless you are on the good meth or at some kind of crazy multi-day convention, you should sleep. If your insomnia gets you past this day, you should seriously take some sleeping pills.
day 3: YOU ARE DAMAGING YOUR HEART. Your body is not built for this. Visual hallucinations of things melting and wobbling start on this day. Creeping sleep can overcome you, leading to being "jerked awake" by whatever horrible reason it is you still haven't gone to sleep. Your brain is running out of neurotransmitters, if you have made it to this point you should be chugging coffee and B vitamins. You can probably feel individual red blood cells as they move through your veins.
night 3: You are on meth. Comes to grips with the fact the MDMA you have been sold is meth. No one who is not on drugs is awake now. Go on, weigh yourself; the increased metabolism from not sleeping should have knocked a handful of pounds off of you. The insomniacs knocked themselves unconscious with drugs yesterday. Even hardheads are looking at you like this shit is not even cute.
day 4: Even if you don't have insurance, call a doctor. If you are still enjoying yourself, rest assured that the shards of meth you have ingested are of top quality. If crack cocaine has brought you here, you have spent quite a large amount of money. Even the tweakers in the gaming guilds are looking at you like you might steal the copper out of their air conditioning coil. Adderall and Vyvance are both brand names for methampetamine, and if they have brought you here you now know this better than anyone. Lemmy's ghost rises from the grave and begs you to go to rehab.
Night 4: you are going to have a fucking stroke. You know that old meth head with the facial paralysis? Yeah, that guy stayed up past night 4. You have a long conversation with Death where Death breaks the news to you that you have a drug problem and He can no longer hang out with you if you're going to be like this. Hell, if you're staying up past night 4, I don't know how comfortable I am writing this for you. Don't stay up past night 4. Just don't.