I've always felt that the good guys in cartoon series who treat the bad guys like shit, or who are pretentious, condescending, arrogant, presumptuous or prideful... are totally unlikable.
Most of the good guys in Looney Tunes are like that. Bug Bunny and Tweety are the best example. They humiliate and mock the bad guys before hurting them, and that always got me cheering for the bad guys. Creating such an "underdog" effect by having your good guy bully around a "bad guy" isn't exactly what I believe to be good character writing...
Lucky Luke also gives me that vibes, but not with all villains. It's only when he would be facing the Dalton brothers that he'd bother me a lot with his condescending behavior... like he's too sure of himself and just knows that he's going to win. That was always a no no for me.