As far as i'm concerned , if the music is good (define good at your own discretion), it doesn't matter if it's made from real/software instruments, presets, random/expert knob twiddling, samples, farts, if the track is played by a band, a computer or a monkey drummer...
https://www.youtube.com/watch?v=u1ZGIrNf71Q&feature=kp
Me?
I started with presets, at one point, i got curious about how they were created, and now, I'm fond of creating my own patches. I would lie if i said no preset was hurt during the learning process.
I don't use them anymore, because sound design has become part of MY fun, also I have the luxury of "no deadlines", otherwise, i would probably look for presets first.
I like that i become more and more able to predict how a sound will sound :D if i turn knob X 30% to the right, things like that... Turning a simple beep into a living thing.
For drums, orchestral, bass guitars, things like that, i use romplers :)