Distortion can really flatten out the frequency spectrum.. This can be either good or bad depending on what sound you want to get out. But too much distortion and your song will end up sounding like the insides of a recycling plant
If you like excessive distorting, imo youd better fucking make sure all the sound remain distinguishable from one another. To separate your sounds and make them bigger sounding/wider, I suggest panning your sounds left/right with a maximum of 40%, or use the stereo separation knob in the mixer track it was assigned to. And keep things on their own little frequency clouds.
I know how clusterdicked everything gets after all that distortion... Btw there's more to making a sound more unique than just distorting it. But it's still fun to do...in MODERATION
Also one of my favorite things I used to do was distort the f out of a sound with camelcrusher, then automate the cutoff for wubs.
Now I just use the fast lp instead of overly dramatic camelcrusher/vst cutoffs. And I only distort a sound if everything sounds too clean. And vice versa. Clean distortion is best distortion though, cause it can be blasted the loudest :D