I am concerned that human intelligence may be a fleeting harmonic in evolutionary patterns because it threatens its own sustainability. One of many examples: as time goes on, weaponized technology is becoming easier and easier to create and possess. This is inevitable with the progression of human intelligence.
As far as we know, we are the only planet with intelligent life. I think that since we can't find intelligence anywhere else in the cosmos that it's important that we take care of it, and spreading life to further reaches should probably be our #1 priority until we can guarantee life's protection from self destruction.
In the long run though, we will probably learn that life is an agent of entropy and that ultimately our existence will bring the universe to a quicker demise. Maybe intelligent life will be around to be pissed off about that.